The Hippo Pathway: An Emerging Role in Urologic Cancers

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Since 26 August 2022

Title: The Hippo Pathway: An Emerging Role in Urologic Cancers
Author: Cinar, Bekir, Clark Atlanta University
Publication Date: 2021-08
Decade: 2020-2029
Abstract: The Hippo pathway controls several biological processes, including cell growth, differentiation, motility, stemness, cell contact, immune cell maturation, organ size, and tumorigenesis. The Hippo pathway core kinases MST1/2 and LATS1/2 in mammals phosphorylate and inactivate YAP1 signaling. Increasing evidence indicates that loss of MST1/2 and LATS1/2 function is linked to the biology of many cancer types with poorer outcomes, likely due to the activation of oncogenic YAP1/TEAD signaling. Therefore, there is a renewed interest in blocking the YAP1/TEAD functions to prevent cancer growth. This review introduces the Hippo pathway components and examines their role and therapeutic potentials in prostate, kidney, and bladder cancer.
Document Type: text
Format: application/pdf
Medium: articles
Source: American Journal of Clinical and Experimental Urology
Institution: Clark Atlanta University
Handle: http://hdl.handle.net/20.500.12322/cau.ir:2021_cinar_bekir_etal
Rights Statement: http://rightsstatements.org/vocab/InC-EDU/1.0/