Characterization of membrane skeletal proteins from normal and sickle erythrocytes, 1987

Floyd, Carl C.

1987-07-01

Sickle cell anemia is a genetic disease which leads to the polymerization of hemoglobin and subsequent changes in the membrane. The membrane alterations are thought to be the cause of the major symptom of the disease, the vaso-occlusive crisis. The purpose of this investigation was to search for alterations in the membrane skeleton of sickle cell erythrocytes. The membrane skeleton is a protein network which controls the shape and deformability of red blood cells. Several differences were detected between sickle and normal membrane skeletons by using electron microscopy, high resolving electrophoresis, crosslinking reagents, and exogenous proteolytic enzymes. Clarification of the mechanism responsible for these alterations may lead to new therapy for sickle cell disease.

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1987-07-01

Doctor of Philosophy (PhD)

Atlanta University

Department of Biology

Haynes, J. K.

Clark Atlanta University

Georgia--Atlanta

http://hdl.handle.net/20.500.12322/cau.td:1987_floyd_carl_c

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