A Synthetic Development of Imidazo [1,5-a] Pyridine to Salts by Nucleophilic Substitution, 2019

Alsalmi, Mulouk

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Title: A Synthetic Development of Imidazo [1,5-a] Pyridine to Salts by Nucleophilic Substitution, 2019
Author: Alsalmi, Mulouk
Date: 2019-12
Publication Date: 2019-12
Decade: 2010-2019
Abstract: The development of novel imidazopyridines to quaternary ammonium is made by quaternization of the precursors 1,3-diphenylimidazo[1,5-a] pyridine (IMB) and 3-phenyl-1-(pyridin-2-yl) imidazole [1,5-a] pyridine (IMP) with methyl iodide and ethyl iodide. Usually N-alkylation reactions of pyridine or imidazole are performed in polar solvents (acetonitrile, methanol, ethanol, etc.). The reaction with iodomethane afforded the new imidazopyridine (IMPs) salts in high yield ranging from 70-72%. The structures of the synthesized compounds were confirmed with 1H NMR, 13C NMR and UV spectroscopy. The purity was confirmed using TLC. The resultant IMPs salts were soluble in water and some extent in polar solvents such as methanol, dimethyl sulfoxide (DMSO), dichloromethane, and acetone. They also exhibit higher melting point than the IMPs.
Document Type: text
Format: application/pdf
Date of Award: 2019-12
Degree Type: thesis
Degree Name: Master of Science (MS)
Granting Institution: Clark Atlanta University
Department: Department of Chemistry
Advisor: Bu, Xiu R.
Institution: Clark Atlanta University
Geographic Location: Georgia--Atlanta
Handle: http://hdl.handle.net/20.500.12322/cau.td:2019_alsalmi_mulouk_f
Rights Statement: http://rightsstatements.org/vocab/InC-EDU/1.0/